منابع مشابه
Metabolism of kidney cancer: from the lab to clinical practice.
CONTEXT There is increasing evidence for the role of altered metabolism in the pathogenesis of renal cancer. OBJECTIVE This review characterizes the metabolic effects of genes and signaling pathways commonly implicated in renal cancer. EVIDENCE ACQUISITION A systematic review of the literature was performed using PubMed. The search strategy included the following terms: renal cancer, metabo...
متن کاملInhibiting tryptophan metabolism enhances interferon therapy in kidney cancer
Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing. Tryptophan metabolism, which produces immunosuppressive metabolites, is enhanced in RCC. Here we show indolamine-2,3-dioxygenase-1 (IDO1) expression, a kynurenine pathway enzyme, is increased not only...
متن کاملKidney and Phosphate Metabolism
The serum phosphorus level is maintained through a complex interplay between intestinal absorption, exchange intracellular and bone storage pools, and renal tubular reabsorption. The kidney plays a major role in regulation of phosphorus homeostasis by renal tubular reabsorption. Type IIa and type IIc Na(+)/Pi transporters are important renal Na(+)-dependent inorganic phosphate (Pi) transporters...
متن کاملThe kidney and homocysteine metabolism.
Homocysteine (Hcy) is an intermediate of methionine metabolism that, at elevated levels, is an independent risk factor for vascular disease and atherothrombosis. Patients with renal disease, who exhibit unusually high rates of cardiovascular morbidity and death, tend to be hyperhomocysteinemic, particularly as renal function declines. This observation and the inverse relationship between Hcy le...
متن کاملMembrane Watching
Several things, that were not all of my own choosing, have conspired to keep me out of active participation in membrane events for a while. But the spectator sport that I call "membrane watching" is far from dull. It may be as rewarding as such things as birds, Congress, girls, bali games, or the Berkeley campus-particularly when you feel yourself somewhat qualified. Of course you lose the trem...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2018
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.361.6406.988-c